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贻贝黏蛋白的医疗应用进展

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贻贝黏蛋白(MAP)因其包含丰富的赖氨酸、多巴胺和疏水基团,可针对性应用于当前皮肤和黏膜组织的各种适应证,在医疗领域展现出巨大潜力。该文深入探讨了这些蛋白的结构、合成生物学工具在其表达和生物制造中的应用,以及临床研究的最新进展,并从产品分类、注册、行业标准等角度分析了医疗行业相关政策,以便了解其发展现状,为扩展临床应用提供参考。
Progress in medical application of mussel adhesive protein
Mussel mucin(MAP),due to its rich lysine,dopamine and hydrophobic groups,can be tar-geted for various indications applied to current skin and mucosal tissues and shows great potential in the medi-cal field.This article outlines the structure of these proteins,the recent advancement of protein expression and biomanufacturing using various synthetic biology tools,and the status of relevant clinical research.This paper deeply explores the structure of these proteins,application of synthetic biology tools in their expression and biofabrication and the latest progress in clinical research,and analyzes the related policy in the medical indus-try from the angles of the products,classification,registration and industrial standard in order to understand its development status quo and provide reference for extending the clinical application.

mussel adhesive proteindopasynthetic biological technologyreview

邹勇、王兴凯、安柏霖、赵裕栋

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华润医药商业集团医疗器械有限公司,北京 100070

中国科学院深圳先进技术研究院,广东 深圳 518055

深圳柏垠生物科技有限公司,广东 深圳 518107

贻贝黏蛋白 多巴 合成生物技术 综述

2024

重庆医学
重庆市卫生信息中心,重庆市医学会

重庆医学

CSTPCD
影响因子:1.797
ISSN:1671-8348
年,卷(期):2024.53(24)