Influence of vitamin D3 on lipid metabolism and pregnancy complications in pregnant women with polycystic ovary syndrome
Objective To observe the influence of vitamin D3 supplementation on lipid metabolism and pregnancy outcomes in pregnant women with polycystic ovary syndrome.Method From January 2021 to December 2022,50 pregnant women with polycystic ovary syndrome were selected for the observational study and received 400 units of vitamin D3 drops orally every day from 12 weeks of gestation.Another 50 paired pregnant women with polycystic ovary syndrome who gave birth at the same time without taking vitamin D3 were served as the control group.The serum 25-hydroxyvitamin D level and the lipid metabolism parameters at the 37th week of gestation,as well as the pregnancy complications were compared between the two groups.Result Compared with the control group,the serum 25-hydroxyvitamin D level in the observational group was significantly increased[(34.55±5.71)ng/ml vs(19.12±4.57)ng/ml,t=15.497,P＜0.001],while the levels of serum triglyceride[(1.50±0.37)mmol/L vs(1.66±0.42)mmol/L],total cholesterol[(4.66±0.62)mmol/L vs(4.99±0.83)mmol/L]and low-density lipoprotein[(2.69±0.47)mmol/L vs(2.87±0.61)mmol/L]in the observational group were significantly lower than those in the control group(all P＜0.05).The results of correlation analysis showed that the level of serum 25-hydroxyvitamin D at the 37th week of gestation in the observation group was negatively correlated with triglyceride(r=﹣ 0.612,P＜0.001),total cholesterol(r=﹣ 0.670,P＜0.001)and low-density lipoprotein(r=﹣0.688,P＜0.001),but positively correlated with high-density lipoprotein(r=0.652,P＜0.001).The incidence of pregnancy complications in the observation group was significantly lower than that in the control group(64.00%vs 92.00%,χ2=11.422,P=0.001).Conclusion Vitamin D3 supplementation in pregnant women with polycystic ovary syndrome is beneficial to correcting the disorders of lipid metabolism,reducing pregnancy complications and improving the outcome of pregnancy.
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