The history of sericulture,which involves the cultivation of mulberry trees and the rearing of silkworms,has profoundly impacted human civilization.As perennial woody plants,mulberry trees hold significant economic,medicinal,and ecological value.However,molecular biological research on mulberry trees has lagged,with a relatively weak foundation.Since the implementation of the mulberry genome se-quencing project in 2013,research on mulberry trees has entered the genomics era,laying the groundwork for the molecular breeding of these plants.This article begins with the implementation of the mulberry ge-nomic research and systematically summarizes the latest developments in mulberry genomic research,in-cluding sequencing technologies,assembly strategies,quality of genome assembly,and applications based on whole-genome resequencing.In the future,with the continuous innovation of technology,mulberry genomics research will face broader development prospects.This article aims to promote the development of the mulberry industry and to provide theoretical and technical references for the study of forest genomics.