Research Results and Influence of Pan-genome in Silkworms
Pangenomics is the forefront of animal and plant genome research,characterized by compre-hensively revealing the genomic diversity and evolutionary characteristics of species,including large struc-tural variations that cannot be well identified by previous technologies.Pangenomic research provides the most comprehensive genomic information for the systematic analysis of the formation of phenotypic diver-sity and modern breeding,which is of great significance.In 2022,our research team was the first in the world to complete the construction of a silkworm pan-genome,completing three generations of long read sequencing for 545 samples and deep second-generation sequencing for 1 078 samples at once,and making a series of important new discoveries.The pan-genome of silkworms has laid a solid foundation for large-scale and efficient analysis of the genetic basis of important traits in silkworms and effective molecular breeding,promoting sericulture research into a new historical stage,further consolidating China's leading role in this field,and having a profound impact on the development of sericulture science.In the past two years,with the strong support of pan-genome,we have made multiple breakthroughs in the construction of silkworm multi-omics databases,the assembly and analysis of complete W chromosome sequences,and the deciphering of genetic basis of important traits.We have also vigorously promoted the application of the pan-genome in genome selection,molecular design breeding,and other fields.On the occasion of the 2nd anniversary of the publication of the silkworm pan-genome paper,this article summarizes and pros-pects the research results,impacts,and related follow-up work of the project.
Bombyx moriPan-genomeScientific discoveryApplication research
万方数据
维普
