多酚自组装抗菌生物材料的构建及其应用进展
Construction of Polyphenol Self-assembly Antibacterial Biomaterials and Progress in Their Applications
徐伟 1俞蓉欣 2张相春 2张以稳 2陈红平 2田宝明 2郑芹芹 2吴媛媛 3夏琛 4韦兵5
作者信息
- 1. 阜阳师范大学生物与食品工程学院,安徽 阜阳 236037;中国农业科学院茶叶研究所,浙江 杭州 310008
- 2. 中国农业科学院茶叶研究所,浙江 杭州 310008
- 3. 浙江大学茶叶研究所,浙江 杭州 310058
- 4. 杭州英仕利生物科技有限公司,浙江 杭州 310000
- 5. 阜阳师范大学生物与食品工程学院,安徽 阜阳 236037
- 折叠
摘要
细菌感染可引起多种疾病,是全球主要死亡原因之一.抗生素一直是治疗细菌感染类疾病的主要策略,但抗生素的过量和不合理使用已导致多种细菌产生耐药性,严重威胁人类生命健康.植物多酚具有天然的抗菌特性,但酚羟基结构的不稳定性限制了其生物利用.为解决这个难题,研究者将多酚与其他物质自组装构建新型纳米生物材料,不仅提高了多酚稳定性和生物利用率,还使其协同发挥抗菌活性,在抗菌领域中具有巨大的应用潜力和优势.综述了近年来不同类型的多酚自组装生物纳米材料构建策略及抗菌性能,包括多酚-金属、多酚-水凝胶、多酚-壳聚糖、多酚-蛋白质和多酚-脂质体等材料,指出了新型多酚自组装生物材料在抗菌领域应用中面临的问题,并对其应用前景进行了展望.
Abstract
Bacterial infection,a leading cause of global mortality,can result in various diseases.While antibiotics are the primary treatment for infections,their excessive and irrational use has led to the emergence of a variety of bacterial drug resistance,posing a serious threat to human health.Plant polyphenols have natural antibacterial properties,but the instability of the phenolic hydroxyl structure limits their bioavailability.To solve this problem,researchers have explored the self-assembly of polyphenols with other substances to construct new nano-biomaterials.These biomaterials not only enhance the stability and bioavailability of polyphenols but also exhibit synergistic antibacterial activity,showing a great promise in the field of antibacterial applications.This review examined the construction strategies and antibacterial properties of different types of polyphenol self-assembled biomaterials developed in recent years,including polyphenol-metal,polyphenol-hydrogel,polyphenol-chitosan,polyphenol-protein and polyphenol-liposome.Furthermore,the challenges and future prospects of the novel polyphenol self-assembling biomaterials in the field of antibacterial application were discussed.
关键词
多酚/自组装/纳米材料/抗菌应用Key words
polyphenols/self-assembly/nanomaterials/antibacterial applications引用本文复制引用
基金项目
浙江省重点研发计划(2023C02040)
浙江省重点研发计划(2022C04036)
国家自然科学基金(32372757)
国家自然科学基金(52003053)
中国农业科学院创新工程(CAAS-ASTIP-2021-TRI)
国家茶叶产业技术体系(CARS-19)
出版年
2024
国家科技期刊平台
NSTL
万方数据