Construction of Polyphenol Self-assembly Antibacterial Biomaterials and Progress in Their Applications
Bacterial infection,a leading cause of global mortality,can result in various diseases.While antibiotics are the primary treatment for infections,their excessive and irrational use has led to the emergence of a variety of bacterial drug resistance,posing a serious threat to human health.Plant polyphenols have natural antibacterial properties,but the instability of the phenolic hydroxyl structure limits their bioavailability.To solve this problem,researchers have explored the self-assembly of polyphenols with other substances to construct new nano-biomaterials.These biomaterials not only enhance the stability and bioavailability of polyphenols but also exhibit synergistic antibacterial activity,showing a great promise in the field of antibacterial applications.This review examined the construction strategies and antibacterial properties of different types of polyphenol self-assembled biomaterials developed in recent years,including polyphenol-metal,polyphenol-hydrogel,polyphenol-chitosan,polyphenol-protein and polyphenol-liposome.Furthermore,the challenges and future prospects of the novel polyphenol self-assembling biomaterials in the field of antibacterial application were discussed.
国家科技期刊平台
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