表没食子儿茶素没食子酸酯预防并改善非酒精性脂肪性肝病的作用机制及研究进展
The Mechanism and Research Progress of Epigallocatechin Gallate in Improving Non-alcoholic Fatty Liver Disease
陈佳欣 1张锦佳 1左会灵 1焦宇航 1石安华1
作者信息
- 1. 云南中医药大学基础医学院,云南 昆明 650500;云南省高校中医证候微观辨证重点实验室,云南 昆明 650500
- 折叠
摘要
非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)发病率逐年升高,目前尚无特效药物.绿茶的有效成分表没食子儿茶素没食子酸酯(Epigallocatechin gallate,EGCG)在低剂量范围内已被证明对NAFLD 具有良好的改善作用.综述总结了 EGCG 通过抗氧化应激、抗炎、抑制铁死亡、减少脂质生成、调节自噬、调节肠道菌群以及降低胆汁酸代谢等方面延缓 NAFLD 发生发展的部分机制,以期为改善 NAFLD 的深入研究提供启示.
Abstract
The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing year by year and there is no specific drug available. The active ingredient of green tea,epigallocatechin gallate (EGCG),has been widely proven to have a favorable ameliorative effect on NAFLD in the low dose range. Some of the mechanisms by which EGCG delays the development of NAFLD through anti-oxidative stress,anti-inflammation,inhibition of iron death,reduction of lipogenesis,up-regulation of autophagy,modulation of intestinal flora,and reduction of bile acid metabolism were summarized in this paper,so as to provide insights for in-depth research on improving NAFLD.
关键词
非酒精性脂肪性肝病/表没食子儿茶素没食子酸酯/氧化应激/炎症Key words
nonalcoholic fatty liver disease/epigallocatechin gallate/oxidative stress/inflammation引用本文复制引用
基金项目
国家自然科学基金(82360863)
云南省科学技术厅中医联合专项-重点项目(202001AZ070001-005)
出版年
2024
国家科技期刊平台
NSTL
万方数据