Differentiated neurons need to maintain axonal growth and function in a quiescent state.Previous studies have shown that epigallocatechin gallate(EGCG)and L-theanine can maintain the quiescent state of neurons and have neurorestorative effects,although the specific mechanisms are still unclear.In the Aβ25-35-induced PC 12 cell damage model,combined treatment with EGCG and L-theanine improved cell metabolism and repair capacity,enhanced cell viability and showed a significant synergistic effect.Transcriptomic and network pharmacological analyses indicate that EGCG mainly maintains the quiescent state of cells by inhibiting oxidative stress,regulating fatty acid metabolism,and mitigating amyloid protein toxicity stress.L-theanine promotes axonal growth and regulates neuronal metabolism and synaptic function.The combined application of both compounds results in a broader and milder regulation of cellular networks,reducing cellular stress.This study provided theoretical support for the neuroprotective effects of tea and its value in an aging society.
维普
万方数据