Inhibitory effect of curcumol ans α-chlorogenol on the reproductive ability of plateau zokors and plateau pikas
[Objective]To evaluate the effects of sterile baits on the reproduction of plateau pika and plateau zo-kor in the alpine grasslands under field conditions.[Method]Sterile baits containing curcumol were used to measure changes in litter size of the two rodents,while α-chlorogenol was used to assess sperm density,sperm malformation rate,and testicular histology in male plateau zokors and plateau pikas.An independent sample t-test was applied for analysis and comparison.[Result]Compared to the control group without non-dosing,curcumol baits significantly re-duced the litter size of plateau pika(P<0.01)but had no significant effect on plateau zokors.α-chloroproterenol sig-nificantly reduced the sperm density of plateau zokors(P<0.05)and significantly increased the sperm malformation rate of plateau pikas and plateau zokors(P<0.05).However,the organ index of plateau zokors and plateau zokors did not change significantly.Histological analysis revealed that α-chlorogenol reduced the spermatozoa and secretion in the epididymis of plateau zokor,and caused interstitial hemorrhage in the testicular tissue.In plateau pika,reduc-tions in spermatozoa and secretions were observed only in the caudal part of the epididymis.[Conclusion]Curcumol and α-chloroproterenol sterilebaits significantly affect the reproduction of plateau pika by reducing litter size and in-creasing sperm malformation rates.In plateau zokors,α-chlorogenol increases sperm malformation rates but does not significantly impact litter size.
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