The human airway environment is a dynamic environment with bacteria. The poly (p-dioxanone) (PDO) stent implanted in the tracheal is disturbed by the bacterial environment during the degradation process. The in vitro degradation property of PDO woven tracheal stents with bacterial environment was investigated, and the influence of bacteria on the degradation behavior of PDO woven tracheal stents was analyzed. The experimental results showed that the presence of bacteria had a positive effect on the degradation of tracheal stents, which could buffer the change of solution pH values and reduce the degradation rate of stents, so that the stents could maintain sufficient radial support force in the early stage. In the later stage of degradation, the erosion of bacteria could accelerate the degradation of stents, so that the stents could be absorbed as soon as possible. Also, the influences of bacterial strains on the erosion degree of the stent were varied. The interweaving points of the woven structure could lead to the uneven degradation morphology of the finished stents. The research can provides references for further development and application of PDO woven tracheal stents.
维普
万方数据