Effects of Lactobacillus rhamnosus Glory LG12 on intestinal health in mice
In order to investigate the effects of Lactobacillus rhamnosus Glory LG12 on intestinal health,this study administered Lactobacillus rhamnosus Glory LG12 orally to mice.The gut microbiota of mice was counted and its main metabolite short chain fatty acids were measured.The morphology and permeability of the mouse intestinal tissue were observed,and the relative expression levels of tight junction protein and mucin-related genes in mouse intestinal epithelial cells were measured to comprehensively evaluate the impact of the strain on mouse intestinal health.The results showed that medium(1.6×107 CFU·piece-1)and high(1.6×108 CFU·piece-1)doses of Lactobacillus rhamnosus Glory LG12 could increase the body weight of mice,enhance the number of some beneficial bacteria(Bifidobacterium and Lactobacillus)in the intestine of mice,reduce the number of some harmful bacteria(Clostridium perfringens)in the intestine,and increase the content of short-chain fatty acids in the intestine.In addition,oral administration of Lactobacillus rhamnosus Glory LG12 not only did not cause pathological damage to the intestinal tissue of mice,but also improved the intestinal barrier integrity and reduced intestinal permeability.Therefore,it was indicated that Lactobacillus rhamnosus Glory LG12 had a certain beneficial effect on regulating the intestinal microecology of mice.
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