Protective effect of hydroxysafflor yellow A against renal injury in spontaneously hypertensive rats
The effects of hydroxysafflor yellow A(HSYA)on serum biochemistry,oxidative stress and renal pathology in spontaneously hypertensive rat(SHR)were investigated using biochemical assays,HE staining and immunohistochemical techniques.The results showed that compared with the SHR model group,different doses of HSYA could regulate the serum REN,Ang Ⅱ,ALD,ACE,TNF-α andIL-6 levels,increase the SOD and GSH-Px activities in renal tissues,decrease the MDA content,up-regulate the expression of HMGCS2 proteins,and improve the degree of renal pathology in SHR.The study also further provides a theoretical basis and experimental reference for the clinical application of HSYA in the treatment of renal injury in essential hypertension.
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