Using chicken and mouse cochlear damage models,the study elucidates the differences between the two in the process of inner ear hair cell regeneration,with a focus on the combined regulatory role of key signaling pathways such as Notch,Wnt,BMP,FGF,and Hh during hair cell regeneration.Employing adenoviral vector technology to activate multiple signaling pathways can induce supporting cells to exit quiescence,enter the cell cycle,proliferate,and differentiate into new hair cells,achieving a certain degree of hair cell regeneration in mouse models.These studies indicate that the regenerative capacity of mammalian hair cells is limited but can still be induced through precise molecular regulation strategies.This provides theoretical basis and practical approaches for further development of therapeutic interventions based on signaling pathway manipulation,aimed at promoting the rehabilitation of human sensorineural hearing loss.
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