首页|Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction

Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction

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Originating but free from chromosomal DNA,extrachromosomal circular DNAs(eccDNAs)are organized in circular form and have long been found in unicellular and multicellular eukaryotes.Their biogenesis and function are poorly understood as they are characterized by sequence homology with linear DNA,for which few detection methods are available.Recent advances in high-throughput sequencing technologies have revealed that eccDNAs play crucial roles in tumor formation,evolution,and drug resistance as well as aging,genomic diversity,and other biological processes,bringing it back to the research hotspot.Several mechanisms of eccDNA formation have been proposed,including the breakage-fusion-bridge(BFB)and translocation-deletion-amplification models.Gynecologic tumors and disorders of embryonic and fetal development are major threats to human reproductive health.The roles of eccDNAs in these pathological processes have been partially elucidated since the first discovery of eccDNA in pig sperm and the double minutes in ovarian cancer ascites.The present review summarized the research history,biogenesis,and currently available detection and analytical methods for eccDNAs and clarified their functions in gynecologic tumors and reproduction.We also proposed the application of eccDNAs as drug targets and liquid biopsy markers for prenatal diagnosis and the early detection,prognosis,and treatment of gynecologic tumors.This review lays theoretical foundations for future investigations into the complex regulatory networks of eccDNAs in vital physiological and pathological processes.

extrachromosomal circular DNAsgynecologic tumorsreproductionliquid biopsynon-invasive prena-tal testing

Ning Wu、Ling Wei、Zhipeng Zhu、Qiang Liu、Kailong Li、Fengbiao Mao、Jie Qiao、Xiaolu Zhao

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State Key Laboratory of Female Fertility Promotion,Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Center for Reproductive Medicine,Peking University Third Hospital,Beijing 100191,China

National Clinical Research Center for Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China

Key Laboratory of Assisted Reproduction(Peking University),Ministry of Education,Beijing 100191,China

Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Te

Institute of Medical Innovation and Research,Peking University Third Hospital,Beijing 100191,China

Cancer Center,Peking University Third Hospital,Beijing 100191,China

Department of Biochemistry and Biophysics,Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)Clinical Medicine Plus X-Young Scholars Project,Peking UniversityFundamental Research Funds for the Central Universities

3217049332170656BYSYSZKF2022005PKU2023LCXQ036

2024

10.1093/procel/pwad032

蛋白质与细胞

蛋白质与细胞

CSTPCD
影响因子：0.645
ISSN：
年,卷(期)：2024.15(1)
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