首页|Radiation injury and gut microbiota-based treatment

Radiation injury and gut microbiota-based treatment

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The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury(RI).RI is a common disease involving multiple human body parts and organs,yet effective treatments are currently lim-ited.Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI.This article summarizes 10 common types of RI and their possible mechanisms.It also highlights the changes and potential microbiota-based treatments for RI,including probiotics,metabolites,and microbiota trans-plantation.Additionally,a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.

microbiomeionizing radiationradiation-induced injuryshort-chain fatty acidsfecal microbiota trans-plantwashed microbiota transplantationwarnuclearmicrobiota medicine

Weihong Wang、Bota Cui、Yongzhan Nie、Lijuan Sun、Faming Zhang

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Department of Microbiota Medicine and Medical Center for Digestive Diseases,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China

Department of Microbiotherapy,Sir Run Run Hospital,Nanjing Medical University,Nanjing 211166,China

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases,Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi'an 710032,China

National Clinical Research Center for Digestive Diseases,Xi'an 710032,China

Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,School of Medicine,Northwest University,Xi'an 710069,China

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National Key Research and Development Program of ChinaNanjing Medical University Fan Daiming Research Funds for Holistic Integrative Medicine

2021YFA0717004

2024

蛋白质与细胞

蛋白质与细胞

CSTPCD
影响因子:0.645
ISSN:
年,卷(期):2024.15(2)
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