首页|The ubiquitin codes in cellular stress responses

The ubiquitin codes in cellular stress responses

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Ubiquitination/ubiquitylation,one of the most fundamental post-translational modifications,regulates almost every critical cellular process in eukaryotes.Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses,from exogenous factors to cellular reactions,causing a dazzling variety of functional consequences.Various forms of ubiquitin sig-nals generated by ubiquitylation events in specific milieus,known as ubiquitin codes,constitute an intrinsic part of myriad cellular stress responses.These ubiquitination events,leading to proteolytic turnover of the substrates or just switch in functionality,initiate,regulate,or supervise multiple cellular stress-associated responses,supporting adaptation,homeostasis recovery,and survival of the stressed cells.In this review,we attempted to summarize the crucial roles of ubiquitination in response to different environmental and intracellular stresses,while discussing how stresses modulate the ubiquitin system.This review also updates the most recent advances in understanding ubiquitination machinery as well as different stress responses and discusses some important questions that may warrant future investigation.

ubiquitinE3 ligaseenvironmental stressesintercellular stressesstress responsehomeostasis

Xiangpeng Sheng、Zhixiong Xia、Hanting Yang、Ronggui Hu

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Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

State Key Laboratory of Molecular Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China

State Key Laboratory of Animal Disease Control,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 1

Department of Neurology,State Key Laboratory of Medical Neurobiology,Institute for Translational Brain Research,MOE Frontiers Center for Brain Science,Zhongshan Hospital,Fudan University,Shanghai 200032,China

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国家自然科学基金国家自然科学基金Ministry of Science and Technology of ChinaNational Science and Technology Innovation Major Project of China(2030)National Science and Technology Innovation Major Project of China(2030)浙江省科技厅项目Guangzhou Science Innovation and Development ProgramShenzhen-Hong Kong Institute of Brain Science

92253302321712162019YFA08021032021ZD02039002022ZD02126002021C03104201803010092NYKFKT2019006

2024

10.1093/procel/pwad045

蛋白质与细胞

蛋白质与细胞

CSTPCD
影响因子：0.645
ISSN：
年,卷(期)：2024.15(3)
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