首页|Ergothioneine and its congeners:anti-ageing mechanisms and pharmacophore biosynthesis
Ergothioneine and its congeners:anti-ageing mechanisms and pharmacophore biosynthesis
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Ergothioneine,Ovothiol,and Selenoneine are sulfur/selenium-containing histidine-derived natural products widely distributed across different organisms.They exhibit significant antioxidant properties,making them as potential lead compounds for promoting health.Increasing evidence suggests that Ergothioneine is positively correlated with healthy ageing and longevity.The mechanisms underlying Ergothioneine's regulation of the ageing process at cellular and molecular levels are beginning to be understood.In this review,we provide an in-depth and extensive coverage of the anti-ageing studies on Ergothioneine and discuss its possible intracellular targeting pathways.In addition,we highlight the recent efforts in elucidating the biosynthetic details for Ergothioneine,Ovothiol,and Selenoneine,with a particular focus on the study of their pharmacophore-forming enzymology.
Li Chen、Liping Zhang、Xujun Ye、Zixin Deng、Changming Zhao
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Department of Geriatrics,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan 430072,China
Key Laboratory of Combinatory Biosynthesis and Drug Discovery,School of Pharmaceutical Sciences,Ministry of Education,Wuhan University,Wuhan 430072,China
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