首页|Emerging clinical relevance of microbiome in cancer:promising biomarkers and therapeutic targets
Emerging clinical relevance of microbiome in cancer:promising biomarkers and therapeutic targets
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The profound influence of microbiota in cancer initiation and progression has been under the spotlight for years,leading to numerous researches on cancer microbiome entering clinical evaluation.As promising biomarkers and therapeutic targets,the critical involvement of microbiota in cancer clinical practice has been increasingly appre-ciated.Here,recent progress in this field is reviewed.We describe the potential of tumor-associated microbiota as effective diagnostic and prognostic biomarkers,respectively.In addition,we highlight the relationship between microbiota and the therapeutic efficacy,toxicity,or side effects of commonly utilized treatments for cancer,includ-ing chemotherapy,radiotherapy,and immunotherapy.Given that microbial factors influence the cancer treatment outcome,we further summarize some dominating microbial interventions and discuss the hidden risks of these strategies.This review aims to provide an overview of the applications and advancements of microbes in cancer clinical relevance.
microbiomecancerdiagnosisprognosistherapy
Jia-Hao Dai、Xi-Rong Tan、Han Qiao、Na Liu
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State Key Laboratory of Oncology in South China,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510050,China
广州市科技计划Guangdong Basic and Applied Basic Research FoundationFundamental Research Funds for the Central Universities,Sun Yatsen University
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