Applications of genetic code expansion technology in eukaryotes

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外文摘要：Unnatural amino acids(UAAs)have gained significant attention in protein engineering and drug development owing to their ability to introduce new chemical functionalities to proteins.In eukaryotes,genetic code expansion(GCE)enables the incorporation of UAAs and facilitates posttranscriptional modification(PTM),which is not feasible in prokaryotic systems.GCE is also a powerful tool for cell or animal imaging,the monitoring of protein interac-tions in target cells,drug development,and switch regulation.Therefore,there is keen interest in utilizing GCE in eukaryotic systems.This review provides an overview of the application of GCE in eukaryotic systems and discusses current challenges that need to be addressed.

外文关键词：

genetic code expansionunnatural amino acideukaryotesbasic researchtherapeutic applications

作者：

Qiao-ru Guo、Yu J.Cao

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作者单位：

State Key Laboratory of Chemical Oncogenomic,Guangdong Provincial Key Laboratory of Chemical Genomics,Peking University Shenzhen Graduate School,Shenzhen 518055,China

Institute of Chemical Biology,Shenzhen Bay Laboratory,Shenzhen 518132,China

基金：

National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaShenzhen Science and Technology Innovation Program

项目编号：

2019YFA09042002019YFA090610032171464JCYJ20180504165501371

出版年：

2024

DOI：

10.1093/procel/pwad051

蛋白质与细胞

CSTPCD

影响因子：0.645

ISSN：

年,卷(期)：2024.15(5)