首页|Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy

Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy

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The current coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coro-navirus(SARS-CoV-2)remains a threat to pregnant women.However,the impact of early pregnancy SARS-CoV-2 infection on the maternal-fetal interface remains poorly understood.Here,we present a comprehensive analy-sis of single-cell transcriptomics and metabolomics in placental samples infected with SARS-CoV-2 during early pregnancy.Compared to control placentas,SARS-CoV-2 infection elicited immune responses at the maternal-fetal interface and induced metabolic alterations in amino acid and phospholipid profiles during the initial weeks post-infection.However,subsequent immune cell activation and heightened immune tolerance in trophoblast cells established a novel dynamic equilibrium that mitigated the impact on the maternal-fetal interface.Notably,the immune response and metabolic alterations at the maternal-fetal interface exhibited a gradual decline during the second trimester.Our study underscores the adaptive immune tolerance mechanisms and establishment of immu-nological balance during the first two trimesters following maternal SARS-CoV-2 infection.

maternalimmunerebalancingfetalinterfaceSARS

Chenxiang Xi、Zihui Yan、Dandan Bai、Yalin Zhang、Beiying Wang、Xiaoxiao Han、Li Wu、Xiaohui Shi、Zhiyi Hu、Ming Tang、Zhongqu Su、Yingdong Liu、Binya Liu、Jiqing Yin、Hong Wang、Xiaocui Li、Yanping Zhang、Shaorong Gao、Wenqiang Liu

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Shanghai Key Laboratory of Maternal Fetal Medicine,Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital,Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China

Jiaxing Maternity and Child Health Care Hospital,Jiaxing 314050,China

Ministry of Science and Technology of ChinaMinistry of Science and Technology of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of Chinakey project of the Science and Technology of Shanghai Municipalitykey project of the Science and Technology of Shanghai MunicipalityShanghai Municipal Medical and Health Discipline Construction ProjectsChina Postdoctoral Science FoundationPostdoctoral Fellowship Program of CPSFShanghai Municipal HealthShanghai Pilot Program for Basic ResearchShanghai"Medical Academy Rising Star"Young Medical Talents ProgramShanghai First Maternity and Infant Hospital"Talent Reservoir"Sailing ProgramFundamental Research Funds for the Central Universities

2022YFC27022002021YFA11029008202202732270909317210039216820531871448318201030093230068419JC141530021JC14055002017ZZ020152023M732660GZB2023052320214Y0254

2024

10.1093/procel/pwae006

蛋白质与细胞

蛋白质与细胞

CSTPCD
影响因子：0.645
ISSN：
年,卷(期)：2024.15(6)