首页|Long way up:rethink diseases in light of phase separation and phase transition

Long way up:rethink diseases in light of phase separation and phase transition

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Biomolecular condensation,driven by multivalency,serves as a fundamental mechanism within cells,facilitating the formation of distinct compartments,including membraneless organelles that play essential roles in various cellular processes.Perturbations in the delicate equilibrium of condensation,whether resulting in gain or loss of phase separation,have robustly been associated with cellular dysfunction and physiological disorders.As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle,a transformative shift is occurring in our comprehension of disease.Consequently,significant strides have been made in unraveling the profound relevance and potential causal connections between abnormal phase separation and various diseases.This com-prehensive review presents compelling recent evidence that highlight the intricate associations between aberrant phase separation and neurodegenerative diseases,cancers,and infectious diseases.Additionally,we provide a suc-cinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.

multivalencycompartmentsaberrant phase separationtherapeuticsgain or loss of phase separationdiseases

Mingrui Ding、Weifan Xu、Gaofeng Pei、Pilong Li

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State Key Laboratory of Membrane Biology & Frontier Research Center for Biological Structure,School of Life Sciences,Tsinghua University,Beijing 100084,China

Tsinghua-Peking Center for Life Sciences,Beijing 100084,China

NuPhase Therapeutics,Beijing 100083,China

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China

2019YFA0508403323300243210054732100990

2024

10.1093/procel/pwad057

蛋白质与细胞

蛋白质与细胞

CSTPCD
影响因子：0.645
ISSN：
年,卷(期)：2024.15(7)