Preparation and in Vitro Dissolution of Soybean Isoflavone Colon Targeting Sus tained-Release Pellet Capsules
To study the formulation and processing of soybean isoflavone colon targeting sustained- release pellet capsules, and to evaluate its release behavior in vitro. The pellets were prepared by extrusion/spheronization. Orthogonal design was used to screen the formulation of soybean isoflavone sustained- release pellet capsules and to optimize the manufacturing process. The optimized formulation of soybean isoflavone sustained-release pellet capsules and processing followed as :5 g of soybean isoflavone,6 g of HPMC(Hydroxypropyl Methyl Cellulose) ,7 g of EC( Ethyl Cellulose) ,6 g of MCC( Microcrystal-line Cellulose) ,the time of spheronization was 20 mm, and 50 % alcohol as adhesive. The prepared pellets had good spher-onization,the critical angle of plan was 12.4 and the recovery was 93.8 %. Moreover,in vitro release of soybean isoflavone sustained- release pellet capsules properly described by first- order kinetics and the sustained- release of the pellets was evident. The colon targeting sustained- release soybean isoflavone pellets capsules with in vitro sustained release characteristics were successfully prepared.
国家科技期刊平台
NSTL
万方数据
维普
