Analysis of the Pharmacological Effects of Sojae Semen Praeparatum in the Treatment of Osteoporosis Based on Network Pharmacology
In order to explore the effect and mechanism of Sojae Semen Praeparatum in the treatment of osteoporosis,this article adopted the method of network pharmacology,collected the active ingredients and corresponding action targets of Sojae Semen Praeparatum through TCMSP and other databases.The active ingredient-potential disease target network diagram and protein interaction network diagram(PPI)were constructed by Cytoscape software.GO and KEGG enrichment analysis were performed for common targets.The results showed that a total of 51 active constituents of Sojae Semen Praeparatum,6 797 osteoporosis related targets,and 40 common targets were obtained.15 core proteins including IL6,CASP3,et al.were screened through protein interaction network analysis.GO and KEGG enrichment analysis showed that common targets participated in biological processes such as peptide serine phosphorylation,peptide serine modification,and response to steroid hormones,which were mainly related to lipids and atherosclerosis,IL-17,alcoholic liver disease and other signaling pathways.
万方数据
维普
