首页|六味地黄丸联合盐酸多奈哌齐治疗轻中度阿尔茨海默病30例临床观察

六味地黄丸联合盐酸多奈哌齐治疗轻中度阿尔茨海默病30例临床观察

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目的:观察六味地黄丸联合盐酸多奈哌齐治疗轻中度阿尔茨海默病(AD)的临床疗效.方法:将60例肾精亏虚型AD患者随机分为治疗组和对照组,每组各30例.对照组采用盐酸多奈哌齐口服治疗,治疗组在对照组治疗的基础上加服六味地黄丸.比较2组中医证候积分、简易智能精神状态检查量表(MMSE)评分、生活能力评估(ADL)评分.结果:总有效率治疗组为63.3％(19/30),明显高于对照组的43.3％(13/30),差异有统计学意义(P＜0.05);治疗后2组的中医证候积分、MMSE评分、ADL评分均得到改善,且治疗组的改善幅度较对照组大(P＜0.05或P＜0.01).结论:六味地黄丸联合盐酸多奈哌齐可以有效改善轻中度AD患者的临床症状,提高患者智力及生活能力.
Clinical effect of Liuwei Dihuang pills combined with donepezil hydrochloride in treatment of mild-to-moderate Alzheimer's disease:An analysis of 30 cases
Objective:To investigate the clinical effect of Liuwei Dihuang pills combined with donepezil hydrochloride in the treatment of mild-to-moderate Alzheimer's disease(AD).Methods:A total of 60 AD patients with deficiency of kidney-essence were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group were given oral administration of donepezil hydrochloride,and those in the treatment group were given Liuwei Dihuang pills in addition to the treatment in the control group.The two groups were compared in terms of traditional Chinese medicine(TCM)syndrome score,Mini-Mental State Examination(MMSE)score,and Activities of Daily Living(ADL)score.Results:The treatment group had a significantly higher overall response rate than the control group[63.3％(19/30)vs 43.3％(13/30),P＜0.05].After treatment,both groups had improvements in TCM syndrome score,MMSE score,and ADL score,and the treatment group had signifi-cantly greater improvements than the control group(P＜0.05 or P＜0.01).Conclusion:For patients with moderate-to-severe AD,Liuwei Dihuang pills combined with donepezil hydrochloride can effectively improve clinical syn-dromes and enhance intelligence and activities of daily living.

Alzheimer's diseasedeficiency of kidney-essenceLiuwei Dihuang pillsdonepezil hydrochlo-ride

饶桂兰、彭永、张镇群、龙亮、吴思亮

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湖南中医药大学,湖南 长沙,410208

湖南中医药高等专科学校附属第一医院,湖南 株洲,412000

阿尔茨海默病 肾精亏虚证 六味地黄丸 盐酸多奈哌齐

湖南省中医药科研计划重点项目湖南省卫健委重点指导项目湖南省株洲市科技局项目湖南中医药高等专科学校附属第一医院优秀科研创新团队建设项目湖南中医药大学校院联合基金项目

A2023039C2023030765742021-009B2021-0032022XYLH198

2024

10.16808/j.cnki.issn1003-7705.2024.01.002

湖南中医杂志
湖南省中医药研究院

湖南中医杂志

影响因子：0.484
ISSN：1003-7705
年,卷(期)：2024.40(1)
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