Clinical effect of kidney-tonifying and blood-activating prescription in treatment of readhesion after surgery for severe intrauterine adhesion:An analysis of 35 cases
Objective:To investigate the clinical effect of kidney-tonifying and blood-activating prescription in the treatment of readhesion after surgery for severe intrauterine adhesion(IUA)and its effect on β-catenin and CD117 proteins in endometrial tissue.Methods:A total of 70 patients with severe IUA who underwent transcervical resection of adhesions were enrolled and randomly divided into treatment group and control group,with 35 patients in each group.The patients in the control group were given artificial menstrual cycle treatment,and those in the treatment group were given oral administration of kidney-tonifying and blood-activating prescription in addition to the treatment in the control group;the course of treatment was 3 menstrual cycles for both groups.The two groups were observed in terms of traditional Chi-nese medicine(TCM)syndrome score,intrauterine adhesion score,endometrial thickness,uterine volume,and changes in the protein expression levels of β-catenin and CD117,and clinical outcome was evaluated for both groups.Results:There was a significant difference in overall response rate between the treatment group and the control group[85.71％(30/35)vs 77.14％(27/35),P＜0.05].After treatment,both groups had significant changes in TCM syndrome score,intrauterine adhesion score,endometrial thickness,uterine volume,and the protein expression levels of β-catenin and CD117,and there were significant differences in these indices between the two groups after treatment(P＜0.05).Conclusion:For patients with severe IUA,kidney-tonifying and blood-activating prescription can effectively improve postoperative TCM syndrome,alleviate the degree of readhesion,prevent uterine readhesion,and increase the protein expression levels of β-catenin and CD117.
severe intrauterine adhesiontranscervical resection of adhesionskidney-tonifying and blood-acti-vating prescriptionβ-cateninCD117
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