首页|自拟葛丹抗纤方治疗气虚血瘀型口腔黏膜下纤维化中晚期患者50例

自拟葛丹抗纤方治疗气虚血瘀型口腔黏膜下纤维化中晚期患者50例

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目的:观察自拟葛丹抗纤方治疗气虚血瘀型口腔黏膜下纤维化(OSF)中晚期的临床疗效.方法:选取气虚血瘀型OSF中晚期患者100例作为研究对象,将其随机分为治疗组和对照组,每组各50例.治疗组采用葛丹抗纤方治疗,对照组采用曲安奈德治疗,以7d为1个疗程,2组均治疗3个疗程.比较2组患者治疗前后的口腔最大开口度、疼痛程度、口腔健康状况和临床疗效.结果:总有效率治疗组为96.0％(48/50),对照组为88.0％(44/50),2组比较,差异有统计学意义(P＜0.05);2组口腔最大开口度、疼痛视觉模拟评分、口腔健康影响程度量表评分治疗前后组内比较及治疗后各时间节点组间比较,差异均有统计学意义(P＜0.05).结论:葛丹抗纤方能提高OSF中晚期患者临床疗效,改善患者张口受限、口腔黏膜疼痛和口腔健康状况.
Clinical effect of self-made Gedan Kangxian prescription in treatment of patients with advanced oral submucous fibrosis with Qi deficiency and blood stasis:An analysis of 50 cases
Objective:To investigate the clinical effect of self-made Gedan Kangxian prescription in the treatment of patients with advanced oral submucous fibrosis(OSF)with Qi deficiency and blood stasis.Methods:A total of 100 patients with advanced OSF with Qi deficiency and blood stasis were selected as subjects and were ran-domly divided into treatment group and control group,with 50 patients in each group.The patients in the treatment group received Gedan Kangxian prescription,and those in the control group received triamcinolone acetonide;each course of treatment was 7 days,and both groups were treated for 3 courses.The two groups were compared in terms of the degree of maximum mouth opening,pain,oral health status,and clinical outcome before and after treatment.Results:There was a significant difference in overall response rate between the treatment group and the control group[96.0％(48/50)vs 88.0％(44/50),P＜0.05].After treatment,both groups had significant changes in the degree of maximum mouth opening,visual analogue scale score,and Oral Health Impact Profile score,and there were significant differences in these indices between the two groups at each time point after treatment(P＜0.05).Conclusion:For patients with advanced OSF,Gedan Kangxian prescription can improve clinical outcome,limited mouth opening,and oral health status.

oral submucous fibrosisadvancedQi deficiency and blood stasisGedan Kangxian prescrip-tion

谢赛飞、谢辉、郭锦材

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湖南中医药大学,湖南 长沙,410208

长沙市口腔医院,湖南 长沙,410005

湖南中医药大学第一附属医院,湖南 长沙,410007

口腔黏膜下纤维化 中晚期 气虚血瘀证 葛丹抗纤方

湖南省临床医疗技术创新引导项目湖南省自然科学基金项目湖南省长沙市自然科学基金项目湖南省保健专项资金科研项目湖南省医学会临床药学科研基金项目

2020SK532062021JJ70062kq2014019B2020-07B202012

2024

10.16808/j.cnki.issn1003-7705.2024.01.005

湖南中医杂志
湖南省中医药研究院

湖南中医杂志

影响因子：0.484
ISSN：1003-7705
年,卷(期)：2024.40(1)
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