Medication rule and mechanism of action for heart failure with preserved ejection fraction:A study based on data mining and network pharmacology
Objective:To investigate the medication rule and mechanism of action for heart failure with preserved ejection fraction(HFPEF)based on data mining and network pharmacology.Methods:CNKI was searched for articles on traditional Chinese medicine(TCM)treatment of HFPEF published from January 31,2003 to December 31,2022.Traditional Chinese Medicine Inheritance Support System V2.50 was used for medication rule analysis,and network pharmacology was performed for core drugs.Results:A total of 112 valid prescriptions were obtained by data mining,involving 127 TCM drugs,such as Astragalus membranaceus,Salvia miltiorrhiza,and Panax ginseng in the order of frequency of use.Most drugs were warm,cold or neutral in nature and had a sweet,bitter or pungent taste,and they mainly entered the heart,spleen,and lung meridians.A total of 17 drug combina-tions with a frequency of ≥23 times were obtained,involving 9 TCM drugs and 7 combinations of new prescriptions.Core drugs included Salvia miltiorrhiza,Astragalus membranaceus,Semen Lepidii,Panax ginseng,and Ramulus Cin-namomi.Network pharmacology obtained 108 active components of core drugs,91 possible action targets,and 52 in-tersecting targets with HFPEF,such as tumor necrosis factor,interleukin-6,TP53,interleukin-1β,and epidermal growth factor receptor.The core drugs mainly acted on extracellular structures,regulated cell proliferation and apop-tosis,and delayed the progression of HFPEF by inhibiting inflammatory response and atherosclerosis.Conclusion:The principle of TCM treatment of HFPEF is benefiting Qi and nourishing Yin and resolving stasis and promoting the flow of water,and network pharmacology shows that the core drugs exert a therapeutic effect on HFPEF through multiple components,targets,and pathways.
heart failure with preserved ejection fractiontraditional Chinese medicine treatmentnetwork pharmacologydata miningmedication rule
NETL
NSTL
万方数据
