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基于数据挖掘探析张奇文治疗癫痫的用药规律

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目的:基于数据挖掘技术探析全国名中医张奇文治疗癫痫的用药规律.方法:收集1998年9月1日至2019年9月30日张奇文治疗癫痫的医案,对医案中的数据进行规范化处理,构建数据库,应用古今医案云平台V2.3.5对中药使用频次、四气五味、功效归经、关联、聚类等进行分析,并总结临床经验.结果:共筛选出40首处方,中药120味.排前10位的中药分别为全蝎、蜈蚣、僵蚕、炙甘草、麦芽、山楂、钩藤、羚羊角、珍珠、牛黄,药性以平、温为主,药味主要为甘、辛、苦,主要归肝、肺、脾经,功效以通络止痛、攻毒散结、息风镇痉等为主.关联组合支持度高的组合为全蝎-蜈蚣、全蝎-僵蚕、僵蚕-蜈蚣、钩藤-全蝎、钩藤-蜈蚣.结论:张奇文治疗癫痫标本兼顾,治标重视息风,治本重视健脾.
Medication rule of Zhang Qiwen in treatment of epilepsy:A study based on data mining
Objective:To investigate the medication rule of National Famous TCM Doctor Zhang Qiwen in the treatment of epilepsy based on data mining.Methods:Medical records of epilepsy treated by Zhang Qiwen from September 1st,1998 to September 30th,2019 were collected,and standardized processing was performed for the data in the medical records to construct a database.Cloud Platform of Ancient and Modem Medical Records V2.3.5 was used to analyze frequency of use,four properties and five tastes,function,and meridian entry and perform associa-tion rule analysis and cluster analysis,and clinical experience was summarized.Results:A total of 40 prescriptions were obtained,involving 120 TCM drugs.The top 10 TCM drugs were scorpion,centipede,Bombyx batryticatus,Ra-dix Glycyrrhizae Preparata,malt,hawthorn fruit,Uncaria,Comu Saigae Tataricae,pearl,and bezoar.Most drugs were neutral or warm in nature and mainly had a sweet,pungent or bitter taste,and they mainly entered the liver,lung,and spleen meridians.The main functions included dredging collaterals and relieving pain,counteracting toxic sub-stances and resolving static blood,and extinguishing wind and relieving spasm.The drug combinations with the high degree of support were scorpion-centipede,scorpion-Bombyx batryticatus,Bombyx batryticatus-centipede,Uncaria-scorpion,and Uncaria-centipede.Conclusion:Zhang Qiwen addresses both the symptoms and root causes in the treatment of epilepsy,with a focus on extinguishing wind in symptomatic treatment and strengthening the spleen in radical treatment.

epilepsyZhang Qiwendata miningmedication rule

王默然、朱士高、刘茜茜、罗小红

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潍坊市中医院,山东 潍坊,261000

癫痫 张奇文 数据挖掘 用药规律

山东省潍坊市中医药科研项目

WFZYY2022-1-005

2024

湖南中医杂志
湖南省中医药研究院

湖南中医杂志

影响因子:0.484
ISSN:1003-7705
年,卷(期):2024.40(2)
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