Medication rule of Jin Zhe in treatment of adenomyosis:A study based on data mining
Objective:To investigate the medication experience and features of Professor Jin Zhe in the treatment of adenomyosis(AM)based on data mining.Methods:Prescriptions at initial diagnosis were collected from the patients with AM who were diagnosed and treated at the outpatient service of Professor Jin Zhe in Dongfang Hospital,Beijing University of Chinese Medicine,from September 1st,2020 to February 28th,2022,and a database was established for traditional Chinese medicine(TCM)prescriptions.Microsoft Excel 2010 was used for the analy-sis of frequency,nature,taste,and meridian entry,and IBM SPSS Modeler 18.0 and IBM SPSS Statistics 25.0 was used for the analysis of prescriptions in terms of frequency of use,nature/taste/meridian entry,drug factor associa-tion rule,complex network,and hierarchical cluster analysis.Results:A total of 120 TCM prescriptions were includ-ed,involving 148 TCM drugs.Commonly used drugs included Fritillaria thunbergii,Prunella vulgaris,Poria cocos,Lonicera japonica,Panax notoginseng,raw oyster shell,Rhizoma Cyperi,and Rhizoma Corydalis.Most drugs were cold,warm or neutral in nature and had a sweet,bitter or pungent taste,and they mainly entered the liver,kidney,and lung meridians.The association rule analysis obtained 12 commonly used drug combinations,and Chuanxia Ningkun decoction was the commonly used prescription.Conclusion:The basic pathogenesis of AM is intermingled phlegm and blood stasis at the uterus and the thoroughfare-conception meridian,which accumulates to form the dis-ease,and turbid phlegm and blood stasis are the root for treatment.Removing phlegm,resolving static blood,and ac-tivating blood circulation are the main principles for the treatment of AM.
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