Mechanism of action of Yupingfeng powder in treatment of Henoch-Schonlein purpura:A study based on network pharmacology
Objective:To investigate the mechanism of action of Yupingfeng powder in the treatment of Henoch-Schonlein purpura(HSP)based on network pharmacology.Methods:Databases including TCMSP,Pubchem,and Swiss target prediction were used to obtain the active components of Yupingfeng powder and effective target genes.Databases such as Genecards,Disgenet,and OMIM were used to obtain the intersecting targets between the genes associated with HSP and the targets of Yupingfeng powder in the treatment of HSP.STRING database and Cytoscape 3.9.1 software were used to construct an active component-target visualized network and perform a visual analysis.DAVID database was used to per-form gene ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)path-way enrichment analysis.Results:The above analyses obtained 45 active components of Yupingfeng powder,212 drug tar-gets,294 disease targets,and 35 intersecting targets.A protein-protein interaction network was established for the key genes,and the main genes involved included tumor necrosis factor,interleukin-6,vascular endothelial growth factor A,in-terleukin-1β,tumor protein p53,matrix metalloproteinase-9,chemokine(C-C motif)ligand 2,interleukin-10,serpin peptidase inhibitor,and CXC chemokine ligand 8.GO functional enrichment analysis obtained 337 GO terms,among which there were 284 biological processes,35 molecular functions,and 22 cellular components.KEGG pathway enrichment analy-sis obtained 101 signaling pathways,including the AGE-RAGE signaling pathway,the fluid shear stress and atherosclerosis signaling pathway,the lipid and atherosclerosis signaling pathway,the malaria signaling pathway,the interleukin-17 signa-ling pathway,the tumor necrosis factor signaling pathway,and the nuclear factor-kappa B signaling pathway.Conclusion:Yupingfeng powder exerts a therapeutic effect on HSP via multiple components,targets,and pathways.
Yupingfeng powderHenoch-Schonlein purpuramechanism of actionnetwork pharmacology
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