Clinical effect of spleen-strengthening,kidney-tonifying,and blood-activating prescription in treatment of polycystic ovary syndrome-insulin resistance:An analysis of 47 cases
Objective:To investigate the clinical effect and safety of spleen-strengthening,kidney-tonifying,and blood-activating prescription in the treatment of spleen-kidney deficiency and phlegm-dampness stasis of polycystic ovary syndrome-insulin resistance(PCOS-IR).Methods:A total of 100 patients with spleen-kidney deficiency and phlegm-dampness stasis of PCOS-IR were randomly divided into treatment group and control group,with 50 patients in each group.The patients in the control group received lifestyle guidance and metformin,and those in the treatment received spleen-strengthening,kidney-tonifying,and blood-activating prescription in addition to the treatment in the control group;the course of treatment was 12 weeks for both groups.The two groups were observed in terms of overall response,traditional Chinese medicine(TCM)syndrome score,insulin resistance indices(fasting insulin[FINS],Homeostasis Model Assess-ment of Insulin Resistance[HOMA-IR],homeostasis model assessment β-cell function,quantitative insulin sensitivity check index[QUICKI],insulin sensitivity index(ISI)proposed by Li Guangwei,and Bennett ISI,glucose and lipid meta-bolic markers(fasting plasma glucose[FPG],total cholesterol,triglyceride,low-density lipoprotein cholesterol[LDL-C],and high-density lipoprotein cholesterol[HDL-C]),body mass index(BMI),sex hormone indicators(lute-inizing hormone[LH],follicle-stimulating hormone[FSH],LH/FSH ratio,estradiol,serum total testosterone[TT],sex hormone-binding globulin,free androgen index[FAI],and serum calculated free testosterone),menstrual cycle score,and adverse reactions.Results:Five patients were lost to follow-up during treatment,and finally there were 47 patients in the treatment group and 48 patients in the control group.There was a significant difference in overall response rate between the treatment group and the control group[93.6%(44/47)vs 77.1%(37/48),P<0.05].After treatment,the treatment group had significant improvements in TCM syndrome score,insulin resistance indices,FPG,LDL-C,BMI,TT,FAI,and menstrual cycle score(P<0.05),and compared with the control group,the treatment group had significantly better im-provements in TCM syndrome score,FINS,HOMA-IR,QUICKI,ISI proposed by Li Guangwei,BMI,and menstrual cycle score(P<0.05).There were no serious adverse reactions in both growps,indicating good drug safety.Conclusion:In pa-tients with spleen-kidney deficiency and phlegm-dampness stasis of PCOS-IR,spleen-strengthening,kidney-tonifying,and blood-activating prescription combined with conventional Western medicine treatment can effectively improve insulin sensitivity,glucose and lipid metabolism disorders,TCM syndrome,and irregular menstruation.
polycystic ovary syndromeinsulin resistancespleen-kidney deficiency,phlegm-dampness stasisin-tegrated traditional Chinese and Western medicine therapyspleen-strengthening,kidney-tonifying,and blood-activating prescription