甘麦大枣汤加减联合雌激素片治疗围绝经期综合征33例
Clinical effect of modified Ganmai Dazao decoction combined with estrogen tablets in treatment of perimenopausal syndrome:An analysis of 33 cases
郭延玲 1王慧杰1
作者信息
- 1. 洛阳市中心医院中医科,河南 洛阳,471099
- 折叠
摘要
目的:观察甘麦大枣汤加减联合雌激素片对围绝经期综合征(PMS)患者症状及性激素水平的影响.方法:将66例PMS患者按照随机数字表法分为治疗组与对照组,每组各33例.对照组予以雌激素片治疗,治疗组在对照组的基础上加用予以甘麦大枣汤加减治疗.观察2组治疗前后中医证候各项评分、Kupper-man评分、性激素水平[促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)]、氧化应激指标[丙二醇(MDA)、超氧化物歧化酶(SOD)]、不良反应发生情况,并评价临床疗效.结果:总有效率治疗组为93.94％(31/33),显著高于对照组的75.76％(25/33),差异有统计学意义(P＜0.05).2组中医证候各项评分、Kupper-man评分、性激素及氧化应激各项指标治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P＜0.05).2组不良反应总发生率组间比较,差异无统计学意义(P＞0.05).结论:甘麦大枣汤加减联合雌激素片对PMS患者有较好疗效,能够显著改善患者症状及性激素水平,减轻氧化应激反应,同时具有较高安全性.
Abstract
Objective:To investigate the effect of modified Ganmai Dazao decoction combined with estrogen tablets on the symptoms and sex hormone levels of patients with perimenopausal syndrome(PMS).Methods:A total of 66 patients were divided into treatment group and control group using a random number table,with 33 patients in each group.The pa-tients in the control group received estrogen tablets,and those in the treatment group received modified Ganmai Dazao de-coction in addition to the treatment in the control group.The two groups were observed in terms of traditional Chinese medi-cine(TCM)syndrome score,Kupperman score,sex hormone levels(follicle-stimulating hormone,luteinizing hormone,and estradiol),oxidative stress indices(malondialdehyde and superoxide dismutase),and adverse reactions,and clinical outcome was also evaluated.Results:The treatment group had a significantly higher overall response rate than the control group[93.94％(31/33)vs 75.76％(25/33),P＜0.05].After treatment,both groups had significant changes in TCM syndrome score,Kupperman score,sex hormone levels,and oxidative stress indices,and there were significant differences in these indicators between the two groups after treatment(P＜0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P＞0.05).Conclusion:Modified Ganmai Dazao decoction combined with estrogen tablets has a marked effect in patients with PMS and can significantly improve their symptoms and sex hormone levels and alleviate oxidative stress response,with a favorable safety profile.
关键词
围绝经期综合征/甘麦大枣汤加减/雌激素片/性激素Key words
perimenopausal syndrome/modified Ganmai Dazao decoction/estrogen tablets/sex hormone引用本文复制引用
基金项目
河南省中医药传承与创新人才工程(仲景工程)中医药青苗人才培养项目(豫卫中医函[2021]16号)
出版年
2024
国家科技期刊平台
NSTL
万方数据