Clinical effect of modified Ganmai Dazao decoction combined with estrogen tablets in treatment of perimenopausal syndrome:An analysis of 33 cases
Objective:To investigate the effect of modified Ganmai Dazao decoction combined with estrogen tablets on the symptoms and sex hormone levels of patients with perimenopausal syndrome(PMS).Methods:A total of 66 patients were divided into treatment group and control group using a random number table,with 33 patients in each group.The pa-tients in the control group received estrogen tablets,and those in the treatment group received modified Ganmai Dazao de-coction in addition to the treatment in the control group.The two groups were observed in terms of traditional Chinese medi-cine(TCM)syndrome score,Kupperman score,sex hormone levels(follicle-stimulating hormone,luteinizing hormone,and estradiol),oxidative stress indices(malondialdehyde and superoxide dismutase),and adverse reactions,and clinical outcome was also evaluated.Results:The treatment group had a significantly higher overall response rate than the control group[93.94％(31/33)vs 75.76％(25/33),P＜0.05].After treatment,both groups had significant changes in TCM syndrome score,Kupperman score,sex hormone levels,and oxidative stress indices,and there were significant differences in these indicators between the two groups after treatment(P＜0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P＞0.05).Conclusion:Modified Ganmai Dazao decoction combined with estrogen tablets has a marked effect in patients with PMS and can significantly improve their symptoms and sex hormone levels and alleviate oxidative stress response,with a favorable safety profile.
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