Medication rule and mechanism of action of traditional Chinese medicine in treatment of rheumatoid arthritis with deficiency of liver and kidney:A study based on data mining
Objective:To investigate the medication rule of traditional Chinese medicine(TCM)in the treatment of rheumatoid arthritis(RA)with deficiency of liver and kidney and the mechanism of action of core drugs.Methods:CNKI,WANFANG DATA,and VIP were searched for related articles of TCM in the treatment of RA with deficiency of liver and kidney published up to May 5th,2023.R language was used to perform drug frequency analysis,nature/taste/meridian entry analysis,association analysis,cluster analysis,correlation analysis,and core drugs were obtained.TCMSP database was used to obtain the active components of core drugs and their targets,and the intersecting targets of drugs and RA were obtained as core targets.Gene ontology(GO)functional enrichment a-nalysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed.A drug-active component-core target network and a protein-protein interaction network were constructed,and analy-ses were performed to obtain the core components and key targets,with molecular docking performed for validation.Results:A total of 54 prescriptions were obtained,involving 149 TCM drugs.Most drugs had a sweet taste and a warm nature and mainly entered the liver and kidney meridians.A total of 48 association rules were obtained,and the cluster analysis obtained 3 new prescriptions.There were 144 intersecting targets between the core drug combinations and RA,and 29 active components and 39 key targets were obtained.GO functional enrichment analy-sis obtained 1013 terms,and KEGG pathway enrichment analysis obtained 173 pathways.Molecular docking showed good binding between the targets and the core components.Conclusion:Liver-and kidney-tonifying drugs,wind-damp-dispelling drugs,and blood-activating and pain-relieving drugs are mainly used in the TCM treatment of RA with deficiency of liver and kidney,in combination with kidney Yang-warming drugs,spleen-invigorating and Qi-tonifying drugs,and blood-activating and stasis-resolving drugs based on syndrome differentiation.Multiple effective constituents in the core drug combinations exert a therapeutic effect on RA with deficiency of liver and kidney by regulating multiple targets and pathways.
rheumatoid arthritis with deficiency of liver and kidneydata miningnetwork pharmacologymedication rulemechanism of action
NETL
NSTL
万方数据
