摘要
目的:应用中医传承辅助平台(V3.0)对刘敏教授治疗乳腺癌的用药规律进行分析.方法:收集2021年1月至2023年6月刘教授门诊276例乳腺癌患者的首诊处方,采用中医传承辅助平台(V3.0)对其进行标准化录入,构建处方数据库,采用该系统的方剂分析等模块进行数据挖掘,分析处方用药规律.结果:276首处方中,排名前5位的药物为山茱萸、炒白术、炒白芍、淫羊藿、党参;药性以温性频次最高,其次为平、寒、凉、热性;药味以甘味频次最高,其次为辛、苦、酸、咸味;药物归经以肝经频次最高(2004次),其次为脾、肾经;常用的药物组合有山茱萸-炒白术、山茱萸-炒白芍、炒白术-炒白芍、山茱萸-淫羊藿、山茱萸-炒白术-炒白芍.根据药物关联规则演化得到关联规则7个,聚类处方6组.结论:刘教授治疗乳腺癌以补肾健脾疏肝为主,兼以化瘀解毒抗癌,体现了扶正祛邪的用药规律.
Abstract
Objective:To investigate the medication rule of Professor Liu Min in the treatment of breast cancer based on Traditional Chinese Medicine Inheritance Support System(V3.0).Methods:Prescriptions of the first consultation were collected from 276 patients with breast cancer who attended the outpatient service of Profes-sor Liu from January 2021 to June 2023,and Traditional Chinese Medicine Inheritance Support System(V3.0)was used for standardized data entry to establish a database of prescriptions.The modules of this system,including prescription analysis,were used for data mining,and the medication rule of the prescriptions was analyzed.Results:Among the 27 6 prescriptions,the top 5 drugs were Comus officinalis,fried Atractylodes macro-cephala Koidz.,fried Radix Paeoniae Alba,Herba Epimedii,and Codonopsis pilosula.As for the nature of the drug,warm drugs had the highest frequency,followed by neutral,cold,cool,and hot drugs;as for the taste of the drug,the drugs with a sweet taste had the highest frequency,followed by those with a pungent,bitter,sour or salty taste;as for meridian entry,the drugs entering the liver meridian had the highest frequency of 2004 times,followed by those entering the spleen or kidney meridians.Commonly used drug combinations included Comus officinalis-fried Atractylodes macrocephala Koidz.,Comus officinalis-fried Radix Paeoniae Alba,fried Atractylodes macro-cephala Koidz.-fried Radix Paeoniae Alba,Comus officinalis-Herba Epimedii,and Comus officinalis-fried At-ractylodes macrocephala Koidz.-fried Radix Paeoniae Alba.The association rule analysis obtained 7 association rules,and the cluster analysis obtained 6 clusters of prescriptions.Conclusion:In the treatment of breast cancer,Professor Liu mainly applies the principles of tonifying the kidney,invigorating the spleen,and soothing the liver,in combination with stasis-resolving,detoxicating,and antitumor drugs,which reflects the medication rule of strengthening vital Qi and eliminating pathogens.
基金项目
国家自然科学基金面上项目(82274423)
吴门医派专家学术经验继承项目(第二批)(苏中院[2020]81号)
国家科技期刊平台
NSTL
万方数据