Clinical effect of Xiongshi Shiwei Wendan decoction in treatment of stable angina with lower limb atherosclerosis:An analysis of 48 cases
Objective:To investigate the clinical effect of Xiongshi Shiwei Wendan decoction in the treatment of stable angina with lower limb atherosclerosis(LLAS).Methods:A total of 96 patients with stable angina with LLAS and the syndrome of intermingled phlegm and blood stasis were divided into treatment group and control group using a random number table,with 48 patients in each group.The patients in the control group received conventional Western medicine treatment,and those in the treatment group received Xiongshi Shiwei Wendan decoction in addition to the treatment in the control group.The two groups were compared in terms of angina pectoris symptom score,traditional Chinese medicine(TCM)syndrome score,quality of life,blood lipid parameters(total cholesterol[TC]and triglyceride[TG]),high-sen-sitivity C-reactive protein(hs-CRP),hemorheological indices(low-shear blood viscosity,high-shear blood viscosity,and platelet aggregation rate),color Doppler ultrasound of lower extremity arteries,and adverse reactions.Results:The treat-ment group had a significantly higher overall response rate than the control group[97.92％(47/48)vs 83.33％(40/48),P＜0.05].Compared with the control group,the treatment group had significantly better improvements in angina pectoris symptom score,TCM syndrome score,quality of life,blood lipid parameters,hs-CRP,hemorheological indices(low-shear blood viscosity,high-shear blood viscosity,and platelet aggregation rate),and color Doppler ultrasound of low-er extremity arteries after treatment(all P＜0.05).No obvious adverse reactions were observed in either group during treat-ment.Conclusion:Xiongshi Shiwei Wendan decoction has a good clinical effect and a favorable safety profile in the treat-ment of stable angina with LLAS,with a better clinical effect than Western medicine treatment alone.
stable anginalower limb atherosclerosissyndrome of intermingled phlegm and blood stasisXiongshi Shiwei Wendan decoction
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