Clinical effect of Xitong patch in treatment of migraine with blood stasis obstructing the collaterals:An analysis of 41 cases
Objective:To investigate the clinical effect of Xitong patch in the treatment of migraine with blood stasis obstructing the collaterals and its effect on calcitonin gene-related peptide(CGRP)and nitric oxide(NO).Methods:A total of 135 patients were randomly divided into control group 1,control group 2,and treatment group,with 45 patients in each group.The patients in the control group 1 received Xitong patch,those in the control group 2 received rizatriptan benzoate,and those in the treatment group received Xitong patch combined with rizatrip-tan benzoate,with a course of treatment of 1 week.The three groups were compared in terms of the degree of pain based on numerical pain intensity scale(NPIS)and serum levels of CGRP and NO before and after treatment,as well as the onset time and duration of pain-relieving treatment,and overall response was evaluated.Results:A total of 14 patients were lost to follow-up,with 4 patients in the treatment group,5 in the control group 1,and 5 in the control group 2,and finally 121 patients completed the treatment.The treatment group had a significantly higher overall response rate than the control groups 1 and 2[87.80％(36/41)vs 82.50％(33/40)and 62.50％(25/40),P＜0.01 or P＜0.05].Compared with the control group 2,the treatment group and the control group 1 had significantly better serum levels of CGRP and NO and onset time and duration of pain-relieving treatment(P＜0.05),and there were no significant differences in these indices between the treatment group and the control group 1(P＞0.05).Conclusion:Xitong patch has a good analgesic effect in patients with migraine and can shorten the onset time of pain-relieving treatment and prolong the duration of pain-relieving treatment,possibly by reducing the activity of CGRP and NO.
migraineblood stasis obstructing the collateralsXitong patchrizatriptan benzoate
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