Objective:To investigate the mechanism of action of Artemisia capillaris in the intervention of liver fibrosis based on network pharmacology.Methods:TCMSP database was used to obtain the active components and action targets of Artemisia capillaris,and GeneCards and OMIM databases were used to obtain the targets asso-ciated with liver fibrosis.The action targets of the active components of Artemisia capillaris were intersected with the disease targets to obtain the action targets of Artemisia capillaris in the intervention of liver fibrosis.Cytoscape 3.10.0 was used to construct a component-target-disease network,STRING database was used to construct a pro-tein-protein interaction network,and Cytoscape 3.10.0 was used for visualized representation and analy-sis.Metascape database was used to perform the gene ontology(GO)functional enrichment analysis and the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis.Results:A total of 15 effective constit-uents were obtained for Artemisia capillaris,involving 289 action targets,among which the core targets included tumor protein 53,tumor necrosis factor,AKT1,interleukin-6,matrix metalloproteinase-9,caspase-3,hypoxia-in-ducible factor-1,and BCL2.The GO functional enrichment analysis and the KEGG pathway enrichment analysis showed that the main biological processes involved were response to hormone,positive regulation of cell migration,response to bacteria-derived molecules,positive regulation of phosphorus metabolic process,and response to exoge-nous stimulation,and the main signaling pathways involved were the cancer pathway,the lipid and atherosclerosis pathway,the PI3K-Akt pathway,the JAK-STAT pathway,and the NF-κB pathway.Conclusion:Artemisia capillaris has the features of multiple components,targets,and pathways in the intervention of liver fibrosis,which provides a reference for further research.
liver fibrosisArtemisia capillarisnetwork pharmacologymechanism of action
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NSTL
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