Mechanism of action of Xuanyang Wentong decoction in treatment of benign prostatic hyperplasia with kidney-Yang deficiency:A study based on network pharmacology
Objective:To investigate the mechanism of action of Xuanyang Wentong decoction in the treat-ment of benign prostatic hyperplasia(BPH)with kidney-Yang deficiency based on network pharmacology and molecular docking.Methods:TCMSP database was used to identify the potential targets and active components of Xuanyang Wentong decoction in the treatment of BPH with kidney-Yang deficiency,and DrugBank,PharmGkb,and GeneCard databases were used to obtain the targets associated with the disease,which were intersected with the potential targets of Xuanyang Wentong decoction to obtain its core targets in the treatment of BPH with kidney-Yang deficiency.A protein-protein interaction network was constructed and R analysis was per-formed.The gene ontology functional enrichment analysis and the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed for the core targets.Molecular docking was performed between the main active components and the core targets.Results:A total of 115 effective constituents acted on BPH with kid-ney-Yang deficiency,and there were 8 core targets in total,involving multiple signaling pathways such as signal transduction regulation,oxidative stress,and cell apoptosis.Molecular docking showed good binding activities be-tween quercetin and TP53 and between kaempferol and BCL2.Conclusion:Xuanyang Wentong decoction exerts a therapeutic effect on BPH with kidney-Yang deficiency through multiple targets and pathways,which provides a theoretical basis for subsequent studies.
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