Medication rule of sour and sweet traditional Chinese medicine drugs in treatment of ulcerative colitis:A study based on data mining
Objective:To investigate the medication rule of sour and sweet traditional Chinese medicine(TCM)drugs in the treatment of ulcerative colitis(UC).Methods:CNKI and Wanfang Data were searched to collect the TCM prescriptions for the treatment of UC published from January 1,2013 to January 1,2023.After screening,statistical software was used to perform frequency and association analyses of sour and sweet drugs in prescriptions,and a compatibility rule analysis was performed for TCM drugs in the prescriptions containing Radix Paeoniae Alba-Radix Glycyrrhizae.Results:A total of 86 prescriptions were collected,involving 137 TCM drugs,among which there were 65 sour and sweet drugs.The top three sweet drugs in terms of frequency of use were Ra-dix Glycyrrhizae,Atractylodes macrocephala Koidz.,and Poria cocos,and the three sour drugs in terms of fre-quency of use were Radix Paeoniae Alba,Sanguisorba officinalis,and Fructus Pruni Mume.The association net-work showed that Radix Paeoniae Alba-Radix Glycyrrhizae and Radix Paeoniae Alba-Atractylodes macrocephala Koidz.were the main sour-sweet drug combinations.A data analysis was further performed for the prescriptions containing Radix Paeoniae Alba-Radix Glycyrrhizae,and the results showed that Atractylodes macrocephala Koidz.,Saussurea costus,and Coptis chinensis were top three drugs in terms of frequency that were used in com-bination with Radix Paeoniae Alba-Radix Glycyrrhizae.The association rule analysis showed that the drug combi-nations such as Atractylodes macrocephala Koidz.-Poria cocos and Poria cocos-tangerine peel were commonly used in the prescriptions containing Radix Paeoniae Alba-Radix Glycyrrhizae.The TCM drugs were clustered into three categories,i.e.,Coptis chinensis-Saussurea costus-Scutellaria baicalensis-Sanguisorba officinalis-Pulsatil-la chinensis,Atractylodes macrocephala Koidz.-Poria cocos-tangerine peel-Codonopsis pilosula,and Angelica sinensis.Conclusion:Radix Paeoniae Alba-Radix Glycyrrhizae is the main sour-sweet drug combination used for the treatment of UC,and it is often used in combination with heat-clearing,spleen-strengthening,and diuresis-promoting drugs.
ulcerative colitissour and sweet drugs for nourishing Yindata miningmedication rule
万方数据
维普
