Medication rule of traditional Chinese medicine treatment of liver failure:A study based on data mining
Objective:To investigate the medication rule of traditional Chinese medicine(TCM)treatment of liver failure over the past 20 years based on data mining.Methods:Databases including Wanfang Data,CNKI,VIP,SinoMed,and PubMed were searched for clinical articles on TCM treatment of liver failure published from Jan-uary 1,2002 to December 31,2022,and SPSS Modeler 18.0 and SPSS Statistics 26.0 were used for the analysis of medication rule.Results:A total of 128 articles were included,involving 141 TCM prescriptions,which contained 148 TCM drugs.The top five TCM drugs in terms of frequency were Artemisia capillaris,Radix Paeoniae Rubra,Ra-dix Glycyrrhizae,Rheum officinale,and Poria cocos,and the top three types of drugs in terms of function were heat-clearing drugs,diuresis-inducing and dampness-draining drugs,and Qi-regulating drugs.Most drugs had a cold,warm,or neutral nature and a bitter,sweet,or pungent taste,and the drugs mainly entered the liver,spleen,and heart meridians.Commonly used drug combinations were Artemisia capillaris-Fructus Gardeniae,Artemisia capillaris-Phellodendri Chinensis Cortex,and Artemisia capillaris-Rheum officinale,and the most commonly used drug combination was Artemisia capillaris-Rheum officinale-Fructus Gardeniae.The cluster analysis obtained five clusters.Conclusion:clearing heat,promoting diuresis and draining dampness,and regulating Qi are the main meth-ods for TCM treatment of liver failure,with a focus on blood-activating and stasis-resolving therapy,as well as the method of tonifying Qi and strengthening vital Qi.
liver failuretraditional Chinese medicine treatmentdata miningmedication rule