摘要
目的:基于数据挖掘技术分析近20年来中医药治疗肝衰竭的用药规律.方法:检索万方数据(WANFANG DATA)、中国知网(CNKI)、维普中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed等数据库2002年1月1日至2022年12月31日发表的关于中医药治疗肝衰竭的临床文献,采用SPSS Modeler 18.0、SPSS Statistics 26.0进行用药规律分析.结果:共纳入文献128篇,涉及中药处方141首,包含148味中药.中药使用频次排名前5位的依次为茵陈、赤芍、甘草、大黄、茯苓;功效排名前3位的是清热药、利水渗湿药、理气药;药性多寒、温、平;药味多苦、甘、辛;归经以肝、脾、心经为主;常用药对组合为茵陈-栀子、茵陈-黄柏、茵陈-大黄,最常用药物组合为茵陈-大黄-栀子;聚类分析得到5个聚类组合.结论:中医药治疗肝衰竭以清热、利水渗湿、理气为主,注重活血化瘀同用,不忘益气扶正.
Abstract
Objective:To investigate the medication rule of traditional Chinese medicine(TCM)treatment of liver failure over the past 20 years based on data mining.Methods:Databases including Wanfang Data,CNKI,VIP,SinoMed,and PubMed were searched for clinical articles on TCM treatment of liver failure published from Jan-uary 1,2002 to December 31,2022,and SPSS Modeler 18.0 and SPSS Statistics 26.0 were used for the analysis of medication rule.Results:A total of 128 articles were included,involving 141 TCM prescriptions,which contained 148 TCM drugs.The top five TCM drugs in terms of frequency were Artemisia capillaris,Radix Paeoniae Rubra,Ra-dix Glycyrrhizae,Rheum officinale,and Poria cocos,and the top three types of drugs in terms of function were heat-clearing drugs,diuresis-inducing and dampness-draining drugs,and Qi-regulating drugs.Most drugs had a cold,warm,or neutral nature and a bitter,sweet,or pungent taste,and the drugs mainly entered the liver,spleen,and heart meridians.Commonly used drug combinations were Artemisia capillaris-Fructus Gardeniae,Artemisia capillaris-Phellodendri Chinensis Cortex,and Artemisia capillaris-Rheum officinale,and the most commonly used drug combination was Artemisia capillaris-Rheum officinale-Fructus Gardeniae.The cluster analysis obtained five clusters.Conclusion:clearing heat,promoting diuresis and draining dampness,and regulating Qi are the main meth-ods for TCM treatment of liver failure,with a focus on blood-activating and stasis-resolving therapy,as well as the method of tonifying Qi and strengthening vital Qi.
维普
万方数据