Medication rule of Yang Fang in syndrome differentiation-based treatment of thyroid nodules:A study based on data mining
Objective:To investigate the prescription and medication rules of Professor Yang Fang in the treatment of thyroid nodules,and to provide a reference for the clinical traditional Chinese medicine(TCM)diagno-sis and treatment of thyroid nodules.Methods:Medical records were collected from the patients with thyroid nodules after syndrome differentiation-based treatment by Professor Yang from October 31,2021 to July 6,2023,and Tradi-tional Chinese Medicine Inheritance Computing System(V3.5)was used to perform data mining of prescriptions and drugs in terms of frequency of use,function,four properties and five tastes,meridian entry,prescription rule,as-sociation rule,and cluster analysis.Results:A total of 160 medical records were included,containing 160 prescrip-tions,which involved 160 TCM drugs.The top five drugs in terms of frequency of use were Poria cocos,Angelica sinensis,Radix Paeoniae Alba,Radix Scrophulariae,and Fritillaria thunbergii.The top three types of drugs in terms of function were deficiency-tonifying drugs,heat-clearing drugs,and phlegm-eliminating,cough-relieving,and asthma-relieving drugs.Most drugs had a cold nature,followed by those with a warm or neutral nature,and most drugs had a sweet taste,followed by those with a bitter or pungent taste.The drugs mainly entered the lung,liver,and stomach meridians.There were 16 core drug combinations with a frequency of use of ≥163 times and 5 new prescription combinations.Conclusion:Professor Yang starts from the lungs,liver,and stomach in the treatment of thyroid nodules and mainly uses deficiency-tonifying drugs,heat-clearing drugs,and phlegm-eliminating,cough-relieving,and asthma-relieving drugs.The new prescription combinations obtained can provide a reference for the clinical treatment of thyroid nodules.