Clinical effect of self-made spleen-invigorating antitumor prescription combined with chemotherapy in treatment of stage Ⅲ gastric cancer with spleen deficiency after surgery:An analysis of 30 cases
Clinical effect of self-made spleen-invigorating antitumor prescription combined with chemotherapy in treatment of stage Ⅲ gastric cancer with spleen deficiency after surgery:An analysis of 30 cases
Objective:To investigate the clinical therapeutic effect of self-made spleen-invigorating antitu-mor prescription combined with chemotherapy on patients with stage Ⅲ gastric cancer with spleen deficiency after surgery.Methods:A total of 60 patients with stage Ⅲ gastric cancer with spleen deficiency after surgery were ran-domly divided into treatment group and control group,with 30 patients in each group.The patients in the treatment group were given self-made spleen-invigorating antitumor prescription combined with postoperative adjuvant chem-otherapy,and those in the control group were given postoperative adjuvant chemotherapy alone.The two groups were compared in terms of overall response rate of TCM syndrome,TCM syndrome score,tumor markers[carcinoembry-onic antigen(CEA)and carbohydrate antigen 199(CA199)],Karnofsky Performance Scale(KPS)score,and re-currence and metastasis rate and survival rate within 6 and 12 months after enrollment,and the incidence rate of ad-verse reactions was also recorded.Results:The patients who completed at least 4 cycles of postoperative adjuvant chemotherapy were included in the analysis of 4 cycles of chemotherapy,with 27 patients in the treatment group and 28 in the control group.The patients who were still alive at 6 months after randomization were further included in the analysis of 6 cycles of chemotherapy,with 29 patients in the treatment group and 27 in the control group.Simi-larly,the patients who were still alive at 12 months after randomization were included in the analysis of 12 cycles of chemotherapy,with 27 patients in the treatment group and 25 in the control group.After 4 cycles of chemotherapy,there was a significant difference in the overall response rate of TCM syndrome between the treatment group and the control group[66.67％(18/27)vs 60.71％(17/28),P＜0.05];at 6 months after chemotherapy,there was a sig-nificant difference in the overall response rate of TCM syndrome between the treatment group and the control group[86.21％(25/29)vs 70.37％(19/27),P＜0.05];at 12 months after chemotherapy,there was a significant difference in the overall response rate of TCM syndrome between the treatment group and the control group[88.89％(24/27)vs 64.00％(16/25),P＜0.05].At 6 and 12 months after chemotherapy,the treatment group had significantly lower levels of CEA and CA199 than the control group(P＜0.05).At 12 months after chemothera-py,the treatment group had a significantly higher KPS score than the control group(P＜0.05).Compared with the control group at 12 months after enrollment,the treatment group had a significantly lower recurrence and metastasis rate[17.24％(5/29)vs 22.22％(6/27),P＜0.05]and a significantly higher survival rate[96.55％(28/29)vs 85.19％(23/27),P＜0.05].Conclusion:For patients with stage Ⅲ gastric cancer with spleen deficiency after surgery,the self-made spleen-invigorating antitumor prescription combined with chemotherapy can significantly al-leviate discomfort symptoms,improve quality of life,reduce recurrence and metastasis rate,and increase survival rate,with no obvious toxic and side effects,and therefore,it holds promise for clinical application.
关键词
胃癌术后/脾虚证/健脾抗癌方/干预作用/临床研究
Key words
gastric cancer after surgery/spleen deficiency/spleen-invigorating antitumor prescription/ther-apeutic effect/clinical research
维普
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