Clinical effect of Paning prescription I in treatment of Parkinson's disease with wind syndrome due to Yang deficiency and dampness-stasis obstruction:An analysis of 42 cases
Objective:To investigate the clinical effect of Paning prescription I in the treatment of Parkin-son's disease(PD)with wind syndrome due to Yang deficiency and dampness-stasis obstruction.Methods:A total of 42 PD patients with wind syndrome due to Yang deficiency and dampness-stasis obstruction were divided into 3-month treatment group with 22 patients and 6-month treatment group with 20 patients according to the time when they attended the hospital,and the course of treatment was 3 and 6 months,respectively.All patients received con-ventional Western medicine treatment combined with Paning prescription Ⅰ.The two groups were observed in terms of traditional Chinese medicine(TCM)syndrome score,Unified Parkinson's Disease Rating Scale Part Ⅲ(UP-DRS Ⅲ)score,non-motor symptom scale(NMSS)score for PD,levodopa equivalent daily dose(LEDD),and ad-verse reactions.Results:There was a significant difference in overall response rate between the 3-month treatment group and the 6-month treatment group[72.73％(16/22)vs 100.00％(20/20),P＜0.05].After treatment,both groups had significant reductions in TCM syndrome score,UPDRS Ⅲ score,NMSS score,and LEDD,and the 6-month treatment group had significantly lower indicators than the 3-month treatment group(P＜0.01).No adverse reaction was observed in either group during treatment.Conclusion:In the treatment of PD with wind syndrome due to Yang deficiency and dampness-stasis obstruction,conventional Western medicine treatment combined with Pa-ning prescription I can improve motor symptoms and non-motor symptoms,alleviate TCM symptoms,and delay dis-ease progression,with a more significant clinical effect with the increase in the time of treatment.
Parkinson's diseasewind syndrome due to Yang deficiency and dampness-stasis obstruc-tionintegrated traditional Chinese and Western medicine therapyPaning prescription Ⅰ
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