Clinical effect of external application of Huaai Xiaoliu ointment in treatment of moderate-to-severe cancer-induced bone pain:An analysis of 30 cases
Objective:To investigate the clinical effect of external application of Huaai Xiaoliu ointment in the treatment of moderate-to-severe cancer-induced bone pain with Yin tumor blocking collaterals.Methods:A total of 90 pa-tients with cancer-induced bone pain with Yin tumor blocking collaterals were divided into treatment group,control group 1,and control group 2 according to the order by which they attended the hospital,with 30 patients in each group.The pa-tients in control group 1 received oxycontin hydrochloride sustained-release tablets in combination with basic treatment in-cluding anti-acid therapy,liver-protecting therapy,and fluid infusion,those in the treatment group received external appli-cation of Huaai Xiaoliu ointment in addition to the treatment in control group 1,and those in control group 2 received zole-dronic acid in addition to the treatment in the control group 1;the course of treatment was 7 days for all three groups.The three groups were compared in terms of numerical rating scale(NRS)pain score,Karnofsky Performance Scale(KPS)score,number of times of breakthrough pain,dose of opioid painkillers,and plasma endothelin-1(ET-1)level.Adverse reactions were observed,and overall response was assessed.Results:The overall response rate was 96.6％(29/30)in the treatment group,83.4％(25/30)in control group 1,and 90.0％(27/30)in control group 2,and there was a significant difference between the three groups(x2=13.169,P=0.034);the treatment group and control group 2 had a significantly better treatment response rate than control group 1(P＜0.05),while there was no significant difference between the treat-ment group and control group 2(P＞0.05).There were significant differences between the three groups in NRS score,KPS score,the number of times of breakthrough pain,the dose of opioid painkillers,and the plasma level of ET-1 before and af-ter treatment(P＜0.05);after treatment,the treatment group had significantly lower NRS score and dose of opioid painkill-ers than control groups 1 and 2,a significantly higher KPS score than control group 1,and significantly lower number of times of breakthrough pain and ET-1 level than control group 2(P＜0.05 or P＜0.01).During observation,mild local pru-ritus was observed in 2 patients in the treatment group and 1 patient each in control groups 1 and 2,and the symptom was controlled after symptomatic treatment.Conclusion:External application of Huaai Xiaoliu ointment in addition to basic treatment has a marked clinical effect in the treatment of cancer-induced bone pain with Yin tumor blocking collaterals,with good safety,reliability,and tolerability,and it holds promise for further research and application.
cancer-induced bone painYin tumor blocking collateralsHuaai Xiaoliu ointmentpain scorequali-ty of life scoreendothelin-1
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