Medication rule and academic thinking of Wang Shuchen in treatment of lung cancer:A study based on data mining
Objective:To investigate the medication rule of Professor Wang Shuchen in the treatment of lung canc-er,and to summarize his academic thinking in the treatment of lung cancer.Methods:Medical records were collected from the patients with lung cancer who were diagnosed and treated at the outpatient service of Professor Wang in Xiyuan Hospital,China Academy of Chinese Medical Sciences,from January 1,2020 to April 30,2023.Excel software was used to extract the data on prescriptions and drugs,and R language was used to analyze the frequency and category of traditional Chinese medi-cine(TCM)drugs and perform association rule analysis and cluster analysis.Results:A total of 325 prescriptions were in-cluded,involving 243 TCM drugs.The accumulative frequency of use of TCM drugs reached 6831,and there were 21 TCM drugs with a frequency of ≥ 100,with the top five drugs of Astragalus membranaceus,Scutellaria barbata,Cremastrae Pseudobulbus,Euonymus alatus,and Cortex Mori.In terms of category,heat-clearing and detoxicating drugs,blood-activating and stasis-resolving drugs,and phlegm-eliminating,cough-relieving,and asthma-relieving drugs were mainly used for treat-ment.A total of 213 association rules were obtained,and Astragalus membranaceus,Aspongopus Chinensis Dallas,pillbug,Cremastrae Pseudobulbus,and Scutellaria barbata were the core drug combinations for the treatment of lung cancer.Common-ly used drug combinations included Aspongopus Chinensis Dallas-pillbug,scorpion-centipede,Cremastrae Pseudobulbus-Scutellaria barbata,Solanum lyratum Thunb.-Sedum sarmentosum,Cortex Mori-Cortex Lycii Radicis,and Rhizoma Dioscore-ae Nipponicae-Pheretima.The cluster analysis obtained 5 clusters.Conclusion:Professor Wang applies the principle of strengthening vital Qi and eliminating pathogens in the treatment of lung cancer,emphasizes the importance of"Tong"(un-blocking),and uses Astragalus membranaceus to address the root cause and to tonify deficiency while clearing stagnation,in combination with lung-clearing and detoxicating drugs,phlegm-eliminating and static blood-resolving drugs,and blood-acti-vating and diuresis-inducing drugs to attack the pathogens.Professor Wang also uses insect-derived drugs to search out pathogens and clear the collaterals and to dissolve masses and disperse nodules,and performs syndrome differentiation-based treatment according to the symptoms of patients and using modified core prescriptions.
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