Medication rule of traditional Chinese medicine in treatment of polycystic ovary syndrome:A study based on data mining
Objective:To investigate the medication rule of traditional Chinese medicine(TCM)in the treatment of polycystic ovary syndrome(PCOS)based on data mining.Methods:CNKI,Wanfang Data,and VIP were searched for articles on TCM treatment of PCOS published up to February 28,2023,and a database was estab-lished after screening.Traditional Chinese Medicine Inheritance Support System(V3.0)was used to analyze the TCM syndromes of PCOS,high-frequency drugs,drug combinations,clusters,and commonly used TCM drugs and core drug combinations during the postmenstrual period,the intermenstrual period,the premenstrual period,and the menstrual period.Results:PCOS was associated with 53 TCM syndromes,with phlegm-dampness syndrome as the most common syndrome.A total of 919 prescriptions were obtained,involving 313 TCM drugs,among which the top 5 drugs were Angelica sinensis,China dodder seed,Poria cocos,prepared Radix Rehmanniae,and Rhizoma Cyperi.The TCM drugs used were mainly deficiency-tonifying drugs,blood-activating and stasis-resolving drugs,and Qi-regulating drugs.The analysis obtained 10 commonly used drug combinations,15 associated drug combinations,and 3 core drug combinations.There were 118 prescriptions used during the postmenstrual period,involving 147 TCM drugs,among which the top 5 drugs were China dodder seed,prepared Radix Rehmanniae,Angelica sinensis,Poria cocos,and Comus officinalis,and there were 3 core drug combinations.There were 102 prescriptions used during the intermenstrual period,involving 153 TCM drugs,among which the top 5 drugs were Angelica sinensis,China dodder seed,Poria cocos,prepared Radix Rehmanniae,and Salvia miltiorrhiza,and there were 3 core drug combinations.There were 104 prescriptions used during the premenstrual period,involving 149 TCM drugs,among which the top 5 drugs were China dodder seed,Angelica sinensis,Poria cocos,Rhizoma Cyperi,and prepared Radix Rehmanniae,and there were 3 core drug combinations.There were 73 prescriptions used during the premenstrual period,involving 128 TCM drugs,among which the top 5 drugs were Angelica sinensis,Rhizoma Cyperi,Herba Leonuri,Poria cocos,and Salvia miltiorrhiza,and there were 3 core drug combinations.Conclusion:The TMC treatment of PCOS high-lights the importance of tonifying the kidney and nourishing essence and emphasizes the methods of activating blood,resolving stasis,regulating Qi,resolving phlegm,and eliminating dampness.Nourishing kidney-essence is the main therapy during the postmenstrual period,and thus Zuogui decoction and Yangjing Zhongyu decoction are used;both kidney-tonifying therapy and blood-activating and stasis-resolving therapy are emphasized during the inter-menstrual period,and thus Liuwei Dihuang pills combined with Siwu Decoction are used;tonifying kidney Yang is the focus during the premenstrual period,and prescriptions should be developed based on the methods of strengthe-ning the spleen,regulating Qi,and tonifying the kidney to strengthen Yang;regulating Qi and activating blood are important during the menstrual period,and thus Siwu Decoction is used.
polycystic ovary syndrometraditional Chinese medicine treatmentmedication ruledata mining
NETL
NSTL
万方数据
