Medication rule of Gu Nailong in treatment of menopause-like syndrome after endocrine therapy for breast cancer:A study based on data mining
Objective:To investigate the medication characteristics and rule of Chief Physician Gu Nailong in the treatment of menopause-like syndrome after endocrine therapy for breast cancer based on data mining and statistical analyses.Methods:A retrospective analysis was performed for the patients with menopause-like syndrome after endocrine therapy for breast cancer who were diagnosed and treated in the outpatient and inpatient departments of Urumqi Hospital of Traditional Chinese Medicine from January 1,2015 to October 31,2022 and revisited the hos-pital for more than three times.Related information was entered into Traditional Chinese Medicine Inheritance Sup-port System V2.5,and statistics and analyses were performed for syndrome type and principle of treatment,as well as the frequency of use,nature/taste,meridian entry,drug type,association rule,and hierarchical clustering of tradi-tional Chinese medicine(TCM)drugs in prescriptions.Results:A total of 240 cases were included.TCM syndrome differentiation showed the highest frequency of stagnated heat in liver meridian,and the principle of treatment was clearing liver-fire,resolving stagnation,cooling blood,and regulating menstruation.A total of 240 prescriptions were collected,involving 84 TCM drugs,and there were 26 drugs with a frequency of use of＞30 times.Most drugs had a warm,neutral or cold nature and a sweet,bitter or pungent taste,and they mainly entered the liver,spleen,and kid-ney meridians.Deficiency-tonifying and Qi-regulating drugs showed the highest frequency.The association analysis obtained 67 core drug combinations,and the cluster analysis obtained 3 clusters of drugs.Conclusion:Chief Physi-cian Gu Nailong applies the basic principle of soothing the liver,strengthening the spleen,and tonifying the kidney in the treatment of this disease and adopts the methods of nourishing the liver and kidney,soothing the liver and strengthening the spleen,and resolving stagnation and clearing heat.He believes that antitumor therapy can be per-formed during the process of improving adverse reactions caused by endocrine therapy.
breast cancermenopause-like syndromeGu Nailongdata miningmedication rule
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万方数据
