Mechanism of action of Hu Yuheng's antihypertensive prescription in treatment of hypertension:A study based on network pharmacology
Objective:To investigate the mechanism of action of Hu Yuheng's antihypertensive prescription in the treatment of hypertension based on network pharmacology.Methods:Related databases were used to obtain the intersecting genes between the target genes of Hu Yuheng's antihypertensive prescription and the genes of hy-pertension.Cytoscape 3.9.1 was used to construct a traditional Chinese medicine(TCM)compound-target net-work and a protein-protein interaction(PPI)network,and gene ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed for the key tar-gets.Results:A total of 23 main active components were obtained,including luteolin,quercetin,kaempferol,and ba-icalein,and a total of 117 potential targets were obtained for Hu Yuheng's antihypertensive prescription in the treat-ment of hypertension.The PPI analysis obtained 59 core genes,including SRC,PI3KR1,PTPN11,and AKT1.The GO analysis obtained 29 biological processes,among which the G protein-coupled receptor signaling pathway,pro-tein phosphorylation,positive regulation of protein kinase-B signal,positive regulation of MAP kinase activity,the transmembrane receptor protein tyrosine kinase signaling pathway,and inflammatory response involved a relatively high number of targets.The KEGG analysis obtained 44 related signaling pathways,among which neuroactive ligand-receptor interaction,the calcium signaling pathway,nitrogen metabolism,and endocrine resistance involved a relatively high number of targets.Conclusion:Hu Yuheng's antihypertensive prescription exerts an antihypertensive effect through multiple targets,paths,and pathways via the components such as luteolin,quercetin,kaempferol,and ba-icalein,and the mechanism of this prescription may be associated with neuroactive ligand-receptor interaction and the calcium signaling pathway.Further studies such as cell and animal experiments are needed to verify such results.
hypertensionHu Yuheng's antihypertensive prescriptionnetwork pharmacologymechanism of action
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