Objective:To investigate the mechanism of action of Xiaoer Tuire oral liquid in the treatment of cold based on network pharmacology and molecular docking.Methods:HIT database was used to obtain the components and targets of Xiaoer Tuire oral liquid,and GeneCards database was used to obtain the action targets of cold.STRING data-base was used to establish a protein-protein interaction network for Xiaoer Tuire oral liquid and cold,and DAVID data-base was used to perform gene ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis.Molecular docking techniques were used to perform molecular doc-king between the main active components and the core targets.Results:A total of 253 components were obtained for Xiaoer Tuire oral liquid,and there were 247 targets acting on cold,including TP53,AKT1,IL-6,TNF,and IL-1β.The pathways involved included the PI3K-Akt signaling pathway,the TNF signaling pathway,and the interleukin signaling pathway.A relatively large absolute value was obtained for the binding energy between STAT3 and progesterone,be-tween TP53 and ursolic acid,and between IL-6 and ursolic acid.Conclusion:Xiaoer Tuire oral liquid involves multiple components,targets,and pathways in the treatment of cold,which might be associated with the mechanism of action of anti-inflammation.These results provide a reference for subsequent studies.
NETL
NSTL
万方数据
