Clinical effect of Ganxi Tablet in treatment of advanced primary liver cancer:A retrospective cohort study
Objective:To investigate the clinical effect of Ganxi Tablet in the treatment of advanced primary liver cancer.Methods:A retrospective analysis was performed for the clinical data of 103 patients with advanced primary liver cancer who were treated in Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine,among whom 55 patients received oral administration of Ganxi Tablet(treatment group)and 48 received oral administration of Compound Cantharidin Capsule(control group).The course of treatment was 2 months for both groups.The two groups were compared in terms of Karnofsky Performance Status(KPS)score,tumor markers,liver function,immune factors,survival time,and adverse drug reactions,and clinical outcome was assessed.Results:There was a significant difference in overall response rate between the treatment group and the control group[81.82％(45/88)vs 60.41％(29/48),P＜0.05].After treatment,both groups had significant changes in KPS score and the expression levels of tumor markers and immune factors,and there were significant differences in these indicators between the two groups after treatment(P＜0.01).Both groups had a significant change in liver function after treatment(P＜0.01),but with no significant difference between the two groups after treatment(P＞0.05).The treatment group had a significantly longer survival time than the control group(P＜0.05).No adverse drug reaction was observed in either group.Conclusion:For patients with advanced primary liver cancer,Ganxi Tablet can improve liver func-tion,reduce the expression levels of tumor markers,improve immunity and activities of daily living,and prolong survival time.
primary liver cancerGanxi TabletPan Minqiuretrospective cohort study
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