Medication rule of Wang Fang in treatment of seasonal allergic conjunctivitis:A study based on data mining
Objective:To investigate the medication rule of Professor Wang Fang in the treatment of season-al allergic conjunctivitis(SAC).Methods:Medical records were collected from the patients with SAC who attended the outpatient service of Professor Wang in The Second Affiliated Hospital of Guizhou University of Traditional Chi-nese Medicine from January 1,2021 to January 1,2024.Excel was used to analyze the frequency of use,nature/taste,and meridian entry of drugs,and Rstudio 4.3.2 was used to perform association rule analysis and cluster anal-ysis.Results:A total of 164 prescriptions were included,involving 171 drugs.The top five drugs in terms of fre-quency of use were Radix Glycyrrhizae Preparata,Divaricate Saposhnikovia Root,Radix Paeoniae Alba,Radix Stel-lariae,and tangerine peel.Most drugs used were cold in nature,followed by those with a warm or neutral nature,and most drugs had a sweet,bitter,or pungent taste;the drugs mainly entered the spleen,liver,lung,and stomach me-ridians.The association rule analysis of high-frequency drugs showed that commonly used drug combinations includ-ed Cacumen biotae-Divaricate Saposhnikovia Root,Cacumen biotae-Radix Stellariae,Radix Stellariae-Divaricate Saposhnikovia Root,(Cacumen biotae/Radix Stellariae)-Divaricate Saposhnikovia Root,(Flos Magnoliae/Radix Stellariae)-Divaricate Saposhnikovia Root,and(Radix Paeoniae Alba/Cacumen biotae)-Divaricate Saposhnikovia Root.The cluster analysis of high-frequency drugs obtained four drug combinations.Conclusion:Professor Wang a-dopts the basic principle of supporting earth and inhibiting wood and the basic treatment methods of strengthening the spleen and clearing liver-fire and dispelling pathogenic wind and arresting itching,with emphasis on the combi-nation of spleen-tonifying and Qi-tonifying drugs,drugs for clearing liver-fire and improving eyesight,and drugs for dispelling pathogenic wind and arresting itching.
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